Calcipotriol (hydrate)
货号：
10009599-500mg 基本售价：
27440.0 元 规格：
500 mg
产品信息
概述| 货号 | 10009599-500mg |
| 描述 | Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3).1 Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response.2 Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.3 |
| 别名 | Calcipotriene; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kragballe, K. Vitamin D analogues in the treatment of psoriasis. Journal of Cellular Biochemistry 49, 46-52 (1992).
2.Johansen, C.,Kragballe, K.,Rasmussen, M., et al. Activator protein 1 DNA binding activity is decreased in lesional psoriatic skin compared with nonlesional psoriatic skin. British Journal of Dermatology 151, 600-607 (2004).
3.Li, M.,Hener, P.,Zhang, Z., et al. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proceedings of the National Academy of Sciences of the United States of America 103(31), 11736-11741 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 412.6 |
| 分子式 | C27H40O3 ?H2O |
| CAS号 | 112828-00-9 |
| 稳定性 | ≥ 2 years |
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