Cylindrospermopsin
货号：
10007867-500ug 基本售价：
27118.0 元 规格：
500 ug
产品信息
概述| 货号 | 10007867-500ug |
| 描述 | Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 µM, respectively), leading to cell death.1 It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 µM.2 Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-0.5 µg/ml.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Runnegar, M.T.,Xie, C.,Snider, B.B., et al. In vitro hepatotoxicity of the cyanobacterial alkaloid cylindrospermopsin and related synthetic analogues. Toxicological Sciences 67, 81-87 (2002).
2.Reisner, M.,Carmeli, S.,Werman, M., et al. The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice. Toxicological Sciences 82, 620-627 (2004).
3.Straser, A.,Filipic, M.,Novak, M., et al. Double strand breaks and cell-cycle arrest induced by the cyanobacterial toxin cylindrospermopsin in HepG2 cells. Mar.Drugs 11(8), 3077-3090 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 415.4 |
| 分子式 | C15H21N5O7S |
| CAS号 | 143545-90-8 |
| 稳定性 | ≥ 1 year |
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