| 货号 | 90030-500ug |
| 描述 | 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature.1 In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction.2 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide.3 20-HETE can be further metabolized by cyclooxygenase to 20-hydroxy PGG2 and 20-hydroxy PGH2.4 |
| 别名 | 20-hydroxy Arachidonic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.McGiff, J.C., and Quilley, J. 20-HETE and the kidney: Resolution of old problems and new beginnings. American Journal of Physiology 277, R607-R623 (1999). 2.Gebremedhin, D.,Lange, A.R.,Lowry, T.F., et al. Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circulation Research 87, 60-65 (2000). 3.Prakash, C.,Zhang, J.Y.,Falck, J.R., et al. 20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine. Biochemical and Biophysical Research Communications 185, 728-733 (1992). 4.Schwartzman, M.L.,Falck, J.R.,Yadagiri, P., et al. Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolites. The Journal of Biological Chemisty 264, 11658-11662 (1989). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 320.5 |
| 分子式 | C20H32O3 |
| CAS号 | 79551-86-3 |
| 稳定性 | ≥ 1 year |
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