CAY10650
货号：
10743-50mg 基本售价：
25480.0 元 规格：
50 mg
产品信息
概述| 货号 | 10743-50mg |
| 描述 | Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.1 CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor.2 It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.2 The phase I metabolite of this compound, CAY10641 (Item No. 10662), is also available. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schaloske, R.H. and Dennis, E.A. The phospholipase A2 superfamily and its group numbering system. Biochemica et Biophysica Acta 1761, 1246-1259 (2006).
2.Drews, A.,Bovens, S.,Roebrock, K., et al. 1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A2α with reduced lipophilicity: Synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity. Journal of Medicinal Chemistry 53, 5165-5178 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 471.5 |
| 分子式 | C28H25NO6 |
| CAS号 | 1233706-88-1 |
| 稳定性 | ≥ 2 years |
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