BLZ-945
货号：
19626-50mg 基本售价：
24920.0 元 规格：
50 mg
产品信息
概述| 货号 | 19626-50mg |
| 描述 | BLZ-945 is a selective inhibitor of the colony stimulating factor 1 receptor (CSF1R) with an IC50 value of 1 nM.1 It is more than 1,000-fold selective against its closest receptor tyrosine kinase homologs.1 It has been shown to inhibit CSF1-dependent proliferation with an EC50 value of 67 nM in bone marrow-derived macrophages.1 In glioma-bearing mice, CSF1R inhibition via BLZ-945 can block tumor progression and significantly improve survival.1 At 200 mg/kg, BLZ-945 decreased the growth of malignant cells in a mouse mammary tumor virus-driven polyomavirus middle T antigen model of mammary carcinogenesis and in a keratin 14-expressing human papillomavirus type 16 transgenic model of cervical carcinogenesis.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pyonteck, S.M.,Akkari, L.,Schuhmacher, A.J., et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 19(10), 1264-1272 (2013).
2.Strachan, D.C.,Ruffell, B.,Oei, Y., et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells. Oncoimmunology 2(12), (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 398.5 |
| 分子式 | C20H22N4O3S |
| CAS号 | 953769-46-5 |
| 稳定性 | ≥ 2 years |
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