Glyco-SPOT DNA Repair Assay Kit
货号：
501280-24dtn 基本售价：
24732.0 元 规格：
24 dtn
产品信息
概述| 货号 | 501280-24dtn |
| 描述 | Base Excision Repair (BER) is the predominant repair pathway responsible for removal of small lesions from DNA, like oxidized, alkylated, deaminated bases and abasic sites. In humans, the mechanism of BER involves the initial action of DNA glycosylases followed by the processing of the resulting abasic site either by the AP-lyase activity of the bifunctional glycosylase or by the apurinic/apyrimiddic endonuclease APE1 that incises the DNA strand. BER mechanisms can be induced by oxidative stress and various genotoxic attacks. The Glyco-SPOT DNA Repair Assay is a multiplexed oligonucleotide cleavage assay developed on support. It is used to monitor simultaneously the cleavage efficiency of several glycosylases/AP endonucleases against a set of emblematic DNA lesions in cell/bacteria/tissue extracts, using fluorescent detection. The assay can be used to screen for DNA repair inhibitors, characterize DNA repair enzymatic signature from samples, check DNA glycosylase specificity, characterize DNA repair inhibitory properties of chemicals (heavy metals …) [Bertin Catalog No. LX05001] |
性能| 供应商 | Cayman |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 稳定性 | ≥ 6 months |
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