| 货号 | 10584-5mg |
| 描述 | S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (−)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM).1 It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity.2,3,4,1 Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 μg/ml, respectively).3,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Borchardt, R.T.,Keller, B.T. and Patel-Thombre, U. Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells. The Journal of Biological Chemisty 259(7), 4353-4358 (1984). 2.Yaginuma, S.,Muto, N.,Tsujino, M., et al. Studies on neplanocin A, new antitumor antibiotic. I. Producing organism, isolation and characterization. Journal of Antibiotics 34(4), 359-366 (1981). 3.De Clercq, E. Antiviral and antimetabolic activities of neplanocins. Antimicrobial Agents and Chemotherapy 28(1), 84-89 (1985). 4.Borcherding, D.R.,Narayanan, S.,Hasobe, M., et al. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase. Journal of Medicinal Chemistry 31, 1729-1738 (1988). 5.Tseng, C.K.H.,Marquez, V.E.,Fuller, R.W., et al. Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities. Journal of Medicinal Chemistry 32, 1442-1446 (1989). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 263.3 |
| 分子式 | C11H13N5O3 |
| CAS号 | 72877-50-0 |
| 稳定性 | ≥ 2 years |
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