| 货号 | 13267-5mg |
| 描述 | Myristic acid is a 14-carbon saturated (14:0) fatty acid. In vivo, it is commonly added covalently to the N-terminus of proteins in a co-translational process termed N-myristoylation.1 The sirtuin SIRT6 removes this acyl group from myristoylated TNF-α, enhancing secretion.2 Myristic acid alkyne is a form of this myristic acid (Item No. 13351) with an ω-terminal alkyne. Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azide-alkyne bioconjugation reactions.3,4 Click chemistry has only recently been applied to the study of lipids.2,5 |
| 别名 | Alk-12;13-alkyne Myristic Acid;Click Tag™ Myristic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Farazi, T.A.,Waksman, G., and Gordon, J.I. The biology and enzymology of protein N-myristoylation. The Journal of Biological Chemisty 276(43), 39501-39504 (2001). 2.Jiang, H.,Khan, S.,Wang, Y., et al. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110-113 (2013). 3.Kolb, H.C., and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discovery Today 8(24), 1128-1137 (2003). 4.Lutz, J.F., and Zarafshani, Z. Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry. Advanced Drug Delivery Reviews 60, 958-970 (2008). 5.Vila, A.,Tallman, K.A.,Jacobs, A.T., et al. Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. Chemical Research in Toxicology 21(2), 432-444 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 224.3 |
| 分子式 | C14H24O2 |
| CAS号 | 82909-47-5 |
| 稳定性 | ≥ 1 year |
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