2,3-dinor-8-iso Prostaglandin F2α
货号：
16290-1mg 基本售价：
23912.0 元 规格：
1 mg
产品信息
概述| 货号 | 16290-1mg |
| 描述 | 8-iso Prostaglandin F2α(8-isoPGF2α; 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation.12,3-dinor-8-isoPGF2α is a metabolite of 8-isoPGF2α in humans and rats.2 In these species, exogenously infused 8-isoPGF2α is converted to 2,3-dinor-8-isoPGF1α and (2,3-dinor-8-isoPGF2α.2,3 Rat hepatocytes further metabolize 8-isoPGF2α to another β-oxidation product, 2,3,4,5-tetranor-8-isoPGF2α.22,3-dinor-8-isoPGF2α is present in normal human urine at concentrations of 200-300 pg/ml.2 Its concentration is increased in conditions of oxidative injury (for example, smoking), and correlates well with that of the parent isoprostane, 8-isoPGF2α.2 |
| 别名 | 2,3-dinor-iPF2α-III;2,3-dinor-8-isoPGF2α; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Morrow, J.D.,Hill, K.E.,Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proceedings of the National Academy of Sciences of the United States of America 87, 9383-9387 (1990).
2.Chiabrando, C.,Valagussa, A.,Rivalta, C., et al. Identification and measurement of endogenous β-oxidation metabolites of 8-epi-prostaglandin F2α. The Journal of Biological Chemisty 274, 1313-1319 (1999).
3.Roberts, L.J., II,Moore, K.P.,Zackert, W.E., et al. Identification of the major urinary metabolite of the F2-isoprostane 8-iso-prostaglandin F2α in humans. The Journal of Biological Chemisty 271, 20617-20620 (1996).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 326.4 |
| 分子式 | C18H30O5 |
| CAS号 | 221664-05-7 |
| 稳定性 | ≥ 2 years |
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