| 货号 | 10009437-50mg |
| 描述 | Kifunensine was originally isolated from the actinomycete Kitasatosporia kifunensine No. 9482 and shown to be a weak inhibitor of aryl mannosidase.1,2 It has since been shown to be a potent and selective inhibitor of class I α-mannosidases and may serve as a key inhibitor of glycoprotein biosynthesis.3 Kifunensine inhibits both human endoplasmic reticulum α-1,2-mannosidase I and members of the Golgi subfamily of the class I mannosidases (Golgi α-mannosidase IA, IB, and IC) exhibiting Ki values of 130 and 23 nM, respectively. It also inhibits mung bean α-1,2-mannosidase I with an IC50 value of 20-50 nM.3 Kifunensine can be used to block α-mannosidase I activity at the endoplasmic reticulum (ER), preventing the removal of desired mutated proteins through ER quality control mechanisms.4,5 |
| 别名 | FR900494; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Iwami, M.,Nakayama, O.,Terano, H., et al. A new immunomodulator, FR-900494: Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. Journal of Antibiotics XL(5), 612-622 (1987). 2.Kayakiri, H.,Takase, S.,Shibata, T., et al. Structure of kifunensine, a new immunomodulator isolated from an actinomycete. The Journal of Organic Chemistry 54, 4015-4016 (1989). 3.Hering, K.W.,Karaveg, K.,Moremen, K.W., et al. A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-mannosidase I. The Journal of Organic Chemistry 70, 9892-9904 (2005). 4.Bartoli, M.,Gicquel, E.,Barrault, L., et al. Mannosidase I inhibition rescues the human α-sarcoglycan R77C recurrent mutation. Human Molecular Genetics 17(9), 1214-1221 (2008). 5.Soheili, T.,Gicquel, E.,Poupiot, J., et al. Rescue of sarcoglycan mutations by inhibition of endoplasmic reticulum quality control is associated with minimal structural modifications. Human Mutation 33(2), 429-439 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 232.2 |
| 分子式 | C8H12N2O6 |
| CAS号 | 109944-15-2 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |