JMV3002
货号：
10012699-5mg 基本售价：
22050.0 元 规格：
5 mg
产品信息
概述| 货号 | 10012699-5mg |
| 描述 | Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro.1 At 80 µg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats.1 JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 µg/kg.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Moulin, A.,Demange, L.,Ryan, J., et al. New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations. Journal of Medicinal Chemistry 51, 689-693 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 586.7 |
| 分子式 | C35H34N6O3 |
| CAS号 | 925239-03-8 |
| 稳定性 | ≥ 1 year |
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