| 货号 | 10008639-25mg |
| 描述 | FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1In vivo, FTY720 is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester.2,3 FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.2,3,4 |
| 别名 | FTY720P; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brinkmann, V.,Pinschewer, D.D.,Feng, L., et al. FTY720: Altered lymphocyte traffic results in allograft protection. Transplantation 72, 764-769 (2001). 2.Brinkmann, V.,Davis, M.D.,Heise, C.E., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. The Journal of Biological Chemisty 277(24), 21453-21457 (2002). 3.Mandala, S.,Hajdu, R.,Bergstrom, J., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296, 346-349 (2002). 4.Forrest, M.,Sun, S.Y.,Hajdu, R., et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. Journal of Pharmacology and Experimental Therapeutics 309(2), 758-768 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 387.5 |
| 分子式 | C19H34NO5P |
| CAS号 | 402615-91-2 |
| 稳定性 | ≥ 2 years |
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