Unoprostone isopropyl ester
货号：
16681-50mg 基本售价：
21504.0 元 规格：
50 mg
产品信息
概述| 货号 | 16681-50mg |
| 描述 | Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2α(PGF2α). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway.1 Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost.2 Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2α on FP receptors.3 |
| 别名 | 13,14-dihydro-15-keto-20-ethyl Prostaglandin F2α isopropyl ester;Rescula; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Taniguchi, T.,Haque, M.S.R.,Sugiyama, K., et al. Ocular hypotensive mechanism of topical isopropyl unoprostone, a novel prostaglandin metabolite-related drug, in rabbits. Journal of Ocular Pharmacology 12, 489-498 (1996).
2.Haria, M. and Spencer, C.M. Unoprostone (isopropyl unoprostone). Drugs & Aging 9, 213-218 (1996).
3.Goh, Y. and Kishino, J. Pharmacological characterization of prostaglandin-related ocular hypotensive agents. Japanese Journal of Ophthamology 38, 236-245 (1994).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 424.6 |
| 分子式 | C25H44O5 |
| CAS号 | 120373-24-2 |
| 稳定性 | ≥ 2 years |
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