| 货号 | 17104-5mg |
| 描述 | 4-oxo-2-Nonenal (4-ONE, Item No. 10185) is a product of lipid peroxidation that actively modifies histidine and lysine residues on proteins and causes protein cross-linking.1,2,3,4,5 It also modifies 2-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.1 4-ONE alkyne is an alkyne-tagged electrophile that can be used as a probe to isolate and identify the reaction products of lipid peroxidation using click chemistry.6,7 |
| 别名 | 4-ONE Alkyne;Alkynyl 4-oxo-2-Nonenal;Click Tag™ 4-oxo-2-Nonenal Alkyne; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rindgen, D.,Nakajima, M.,Wehrli, S., et al. Covalent modifications to 2-deoxyguanosine by 4-oxo-nonenal, a novel product of lipid peroxidation. Chemical Research in Toxicology 12, 1195-1204 (1999). 2.Lee, S.H., and Blair, I.A. Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation. Chemical Research in Toxicology 13, 698-702 (2000). 3.Spiteller, P.,Kern, W.,Reiner, J., et al. Aldehydic lipid peroxidation products derived from linoleic acid. Biochimica et Biophysica Acta 1531, 188-208 (2001). 4.Liu, Z.,Minkler, P.E., and Sayre, L.M. Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal. Chemical Research in Toxicology 16, 901-911 (2003). 5.Zhang, W.H.,Liu, J.,Xu, G., et al. Model studies on protein side chain modification by 4-oxo-2-nonenal. Chemical Research in Toxicology 16, 512-523 (2003). 6.Wang, C.,Weerapana, E.,Blewett, M.M., et al. A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. Nature Methods 11(1), 79-85 (2014). 7.Beavers, W.N.,Serwa, R.,Shimozu, Y., et al. ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: Free radical and enzymatic oxidations. Journal of the American Chemical Society 136(32), 11529-11539 (2014). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% |
| 计算分子量 | 150.2 |
| 分子式 | C9H10O2 |
| CAS号 | 1680193-58-1 |
| 稳定性 | ≥ 1 year |
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