| 货号 | 500380-480Solid |
| 描述 | Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenases.1 The 17(R)-epimer of RvD1 can also be generated with aspirin-treatment.2 Both RvD1 and its 17(R) configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation. RvD1 exhibits antihyperalgesic effects in a rat model of adjuvant-induced arthritis and prevents and inhibits the TRP channels, TRPA1, TRPV3, and TRPV4,3,4,5 producing anti-nociceptive effects. Resolvins also specifically interact with human phagocytes via the ALX and GPR32 receptors and have been shown to improve insulin sensitivity in leptin receptor-deficient (db/db) mice, possibly related to the reduction of pro-inflammatory macrophages found in adipose tissues.6,7 Cayman’s Resolvin D1 ELISA Kit is a competitive assay that can be used for quantification of RvD1. Due to the number and variation of potential sample types, this assay has been validated in Cayman’s ELISA Buffer (Item No. 400060) diluted to 1X (0.1 M potassium phosphate containing 0.1% BSA, 0.1% sodium chloride, 1 mM EDTA, and 0.01% sodium azide) and DMEM containing phenol red and 10% FBS. This assay has a range from 3.3-2,000 pg/ml and a sensitivity (80% B/B0) of approximately 15 pg/ml. |
| 别名 | Resolvin D1 EIA Kit;17(S)-Resolvin D1;RvD1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hong, S.,Gronert, K.,Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. The Journal of Biological Chemisty 278(17), 14677-14687 (2003). 2.Serhan, C.N.,Hong, S.,Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals. Journal of Experimental Medicine 196(8), 1025-1037 (2002). 3.Lima-Garcia, J.F.,Dutra, R.C.,da Silva, K., et al. The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats. British Journal of Pharmacology 164, 278-293 (2011). 4.Bang, S.,Yoo, S.,Yang, T.J., et al. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. British Journal of Pharmacology 161, 707-720 (2010). 5.Bang, S.,Yoo, S.,Yang, T., et al. 17(R)-Resolvin D1 specifically inhibits TRPV3 leading to peripheral antinociception. British Journal of Pharmacology (2011). 6.Krishnamoorthy, S.,Recchiuti, A.,Chiang, N., et al. Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proceedings of the National Academy of Sciences of the United States of America 107(4), 1660-1665 (2010). 7.Hellmann, J.,Tang, Y.,Kosuri, M., et al. Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. The FASEB Journal 25, 2399-2407 (2011). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 稳定性 | ≥ 1 year |
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