CAY10626
货号：
13838-25mg 基本售价：
20580.0 元 规格：
25 mg
产品信息
概述| 货号 | 13838-25mg |
| 描述 | Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3 hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3, important second messengers that modulate the activity of downstream targets Akt and mTOR.1 Aberrant PI3K/Akt is associated with many human cancers. CAY10626 is a potent, dual PI3Kα/mTOR inhibitor with IC50 values of 0.9 and 0.6 nM for the two respective kinases.2 In a tumor cell growth inhibition assay, CAY10626 demonstrates IC50 values of <3 and 13 nM for MDA361 (breast) and PC3 (prostate) cancer cell lines, respectively.2 When administered at 25-50 mg/k to MD361 xenograft mice, phosphorylation of the downstream targets of PI3Kα and mTOR (Akt T308, Akt S473, and S6K) was suppressed, and significant tumor regression was observed.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rameh, L.E. and Cantley, L.C. The role of phosphoinositide 3-kinase lipid products in cell function. The Journal of Biological Chemisty 274, 8347-8350 (1999).
2.Chen, Z.,Venkatesan, A.M.,Dehnhardt, C.M., et al. Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent phosphatidylinositol 3-kinase inhibitors. Journal of Medicinal Chemistry 53(8), 3169-3182 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 624.7 |
| 分子式 | C31H35F3N8O3 |
| CAS号 | 1202884-94-3 |
| 稳定性 | ≥ 2 years |
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