| 货号 | 16831-5mg |
| 描述 | Prostaglandin I2(PGI2, prostacyclin) is the most potent endogenous vasodilator that affects both the systemic and pulmonary circulation.1 Cicaprost is a PGI2 analog that is orally active with prolonged availability in vivo, having a terminal half life in plasma of one hour.23 In addition to their effects on smooth muscle, PGI2 analogs, including cicaprost, have been shown to inhibit the pro-inflammatory actions of certain leukocytes, suppress cardiac fibrosis, and block mitogenesis of certain cell types.456 Importantly, cicaprost has been shown to strongly reduce lung and lymph node metastasis in rats, suggesting that it might be useful in cancer therapy.7 |
| 别名 | ZK 96480; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Moncada, S. Biology and therapeutic potential of prostacyclin. Stroke 14, 157-168 (1983). 2.Kiriyama, M.,Ushikubi, F.,Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. British Journal of Pharmacology 122, 217-224 (1997). 3.Hildebrand, M.,Staks, T., and Nieuweboer, B. Pharmacokinetics and pharmacodynamics of cicaprost in healthy volunteers after oral administration of 5 to 20 micrograms. European Journal of Clinical Pharmacology 39(2), 149-153 (1990). 4.Zhou, W.,Hashimoto, K.,Goleniewska, K., et al. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. Journal of Immunology 178, 702-710 (2007). 5.Chan, E.C.,Dusting, G.J.,Guo, N., et al. Prostacyclin receptor suppresses cardiac fibrosis: Role of CREB phosphorylation. Journal of Molecular and Cellular Cardiology 49, 176-185 (2010). 6.Castagnino, P.,Kothapalli, D.,Hawthorne, E.A., et al. Cell-type- and cell-cycle-specific anti-mitogenesis by cicaprost. Prostaglandins & Other Lipid Mediators 93, 20-24 (2010). 7.Schirner, M.,Kraus, C.,Lichtner, R.B., et al. Tumor metastasis inhibition with the prostacyclin analogue cicaprost depends on discontinuous plasma peak levels. Prostaglandins, Leukotrienes and Essential Fatty Acids 58(40, 311-317 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 374.5 |
| 分子式 | C22H30O5 |
| CAS号 | 94079-80-8 |
| 稳定性 | ≥ 1 year |
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