16(S)-Iloprost
货号：
13077-5mg 基本售价：
20496.0 元 规格：
5 mg
产品信息
概述| 货号 | 13077-5mg |
| 描述 | Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.1 Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM.2 Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(S)-Iloprost potently inhibits platelet aggregation with an IC50 value of 3.5 nM.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schrör, K.,Darius, H.,Matzky, R., et al. The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK36374) - equipotent to PGI2 in vitro. Naunyn-Schmiedebergs Archives of Pharmacology 316, 252-255 (1981).
2.Abramovitz, M.,Adam, M.,Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et Biophysica Acta 1483, 285-293 (2000).
3.Tsai, A.L.,Vijjeswarapu, H., and Wu, K.K. Interaction between platelet receptor and iloprost isomers. Biochimica et Biophysica Acta 942, 220-226 (1988).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 360.5 |
| 分子式 | C22H32O4 |
| CAS号 | 74843-14-4 |
| 稳定性 | ≥ 1 year |
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