| 货号 | 9000595-5mg |
| 描述 | CEP-Lysine-d4 contains four deuterium atoms at the carboxyethyl 2,3,3,3 positions. It is intended for use as an internal standard for the quantification of CEP-lysine by GC- or LC-mass spectrometry (MS). Docosahexaenoic acid (DHA) is an ω-3 polyunsaturated fatty acid that is abundant in the brain and in photoreceptor cell membranes in the retina. Oxidative cleavage of phospholipids containing DHA produces reactive electophilic phospholipid fragments, including 4-hydroxy-7-oxohept-5-enoates.1 These can interact with the primary amine group of lysyl residues to produce 2-(ω-carboxyethyl)pyrrole (CEP) derivatives, which are abundant in certain diseases.2,3 Advanced glycation end products, including CEP-lysine are biomarkers for age-related macular degeneration.4,5CEP-lysine-d4 is a deuterated form of CEP-lysine. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lu, L.,Gu, X.,Hong, L., et al. Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: Mediators of age-related macular degeneration. Bioorganic & Medicinal Chemistry 17, 7548-7561 (2009). 2.Gu, X.,Sun, M.,Gugiu, B., et al. Oxidatively truncated docosahexaenoate phospholipids: Total synthesis, generation, and peptide adduction chemistry. The Journal of Organic Chemistry 68, 3749-3761 (2003). 3.Crabb, J.W.,Miyagi, M.,Gu, X., et al. Drusen proteome analysis: An approach to the etiology of age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 99(23), 14682-14687 (2002). 4.Gu, J.,Pauer, G.J.T.,Yue, X., et al. Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers. Mol.Cell.Proteomics 8, 1338-1349 (2009). 5.Ni, J.,Yuan, X.,Gu, J., et al. Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration. Mol.Cell.Proteomics 8, 1921-1933 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 272.3 |
| 分子式 | C13H16D4N2O4 |
| 稳定性 | ≥ 2 years |
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