| 货号 | 10010606-500ug |
| 描述 | 13,14-dihydro-15-keto Prostaglandin E2-d4 (13,14-dh-15-keto PGE2-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-keto PGE2 (Item No. 14650) by GC- or LC-MS. 13,14-dh-15-keto PGE2 is the primary metabolite of PGE2 (Item No. 14010) in plasma.1 Endogenous or infused PGE2 is rapidly metabolized by the enzymes 15-hydroxy PGDH and 15-oxo-PG Δ13-reductase to form 13,14-dh-15-keto PGE2. 13,14-dh-15-keto PGE2 accumulates to detectable levels; plasma levels in humans are between 10-100 pg/ml.2,3 It undergoes further metabolism and chemical decomposition, giving it a relatively short half-life. In dogs, the plasma half-life of 13,14-dh-15-keto PGE2 is about 9 minutes.2 In humans the metabolite has a similar short half-life, making it a poor choice of analytes for assays designed to measure total PGE2biosynthesis.4,5 |
| 别名 | 13,14-dh-15-keto PGE2-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. The Journal of Biological Chemisty 246, 6713-6721 (1971). 2.Bothwell, W.,Verburg, M.,Wynalda, M., et al. A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E1 and E2: An indirect index of their in vivo disposition and pharmacokinetics. Journal of Pharmacology and Experimental Therapeutics 220, 229-235 (1982). 3.Leonhardt, A.,Krauss, M.,Gieler, U., et al. In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. British Journal of Dermatology 136, 337-340 (1997). 4.Fitzpatrick, F.A.,Aguirre, R.,Pike, J.E., et al. The stability of 13,14-dihydro-15 keto-PGE2. Prostaglandins 19, 917-931 (1980). 5.Granström, E.,Hamberg, M.,Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE2: The reason for low assay reliability. Prostaglandins 19, 933-945 (1980). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 356.5 |
| 分子式 | C20H28D4O5 |
| 稳定性 | ≥ 1 year |
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