Sp-8-CPT-Cyclic AMPS (sodium salt)
货号：
21854-10mg 基本售价：
19600.0 元 规格：
10 mg
产品信息
概述| 货号 | 21854-10mg |
| 描述 | Sp-8-CPT-Cyclic AMPS (Sp-8-CPT-cAMPS) is a cell permeable cAMP analog that potently and selectively activates protein kinase A.1 Sp-8-CPT-cAMPS is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs 8-CPT-Cyclic AMP (Item No. 12011) and Sp-Cyclic AMPS (Item No. 14983). It is used to investigate the effects of cAMP-dependent PKA signaling.1 Sp-8-CPT-cAMPS (10 μM; 30 min) reduces the spasmogenic response (pEC50 = 4.74) in guinea-pig trachealis.2 |
| 别名 | Sp-8-CPT-cAMPS; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dostmann, W.R.,Taylor, S.S.,Genieser, H.G., et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3,5-cyclic phosphorothioates. J. Biol. Chem. 265(18), 10484-10491 (1990).
2.Spicuzza, L.,Belvisi, M.G.,Birrell, M.A., et al. Evidence that the anti-spasmogenic effect of the β-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br. J. Pharmacol. 133(8), 1201-1212 (2001).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 509.9 |
| 分子式 | C16H14ClN5O5PS2 • Na |
| 稳定性 | ≥ 2 years |
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