L-threo-Sphingosine C-18
货号：
10010541-100mg 基本售价：
19600.0 元 规格：
100 mg
产品信息
概述| 货号 | 10010541-100mg |
| 描述 | Sphingosines are long-chain base precursors of cellular sphingolipids and are used directly in the synthesis of ceramide. Sphingosine can exist in four stereoisomers, however only D-erythro-sphingosine occurs naturally. L-threo-Sphingosine C-18, an analog of D-erythro-sphingosine, inhibits protein kinase C in mixed micelle assays with 50% inhibition at 2.2 mol % making it a slightly more potent inhibitor compared to D-erythro-sphingosine (50% inhibition at 2.8 mol %) or other analogs of shorter alkyl chain length.1 Addition of L-threo-Sphingosine C-18 to primary cultured cerebellar cells does not decrease serine palmitoyltransferase (SPT) activity, the rate-limiting enzyme in ceramide biosynthesis, whereas under similar conditions D-erythro-sphingosine inhibits SPT activity.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Merrill, A.H., Jr.,Nimkar, S.,Menaldino, D., et al. Structural requirements for long-chain (shingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry 28, 3138-3145 (1989).
2.Mandon, E.C.,van Echten, G.,Birk, R., et al. Shingolipid biosynthesis in cultured neurons: Down-regulation of serine palmitoyltransferase by sphingoid bases. European Journal of Biochemistry 198, 667-674 (1991).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% |
| 计算分子量 | 299.5 |
| 分子式 | C18H37NO2 |
| CAS号 | 25695-95-8 |
| 稳定性 | ≥ 2 years |
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