| 货号 | 2453/50 |
| 别名 | (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[ |
| 供应商 | Tocris |
| 生物活性 | Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. Caged LY 379268 is also available (Cat. No. 3332). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 187.15 |
| 分子式 | C7H9NO5 |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 100 mM in 1eq. NaOH |
| CAS号 | 191471-52-0 |
| 参考文献 | Colladoet al (2002) (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties. J.Med.Chem. 45 3619. PMID: 12166935. Bondet al (2000) Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo. J.Pharmacol.Exp.Ther. 294 800. PMID: 10945827. Bondet al (1999) LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia. Neurosci.Lett. 273 191. PMID: 10515191. |