AL 6598
货号：
13620-10mg 基本售价：
19320.0 元 规格：
10 mg
产品信息
概述| 货号 | 13620-10mg |
| 描述 | Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2α and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 µM and demonstrates an EC50 value of 0.80 µM in an in vitro functional assay.1 Designed to enhance corneal absorption, AL 6598 produces a maximum 53% drop in IOP of the ocular hypertensive monkey with a 1 µg dose given twice daily.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hellberg, M.R.,Conrow, R.E.,Sharif, N.A., et al. 3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents. Bioorganic & Medicinal Chemistry 10, 2031-2049 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 431 |
| 分子式 | C23H39ClO5 |
| CAS号 | 170291-06-2 |
| 稳定性 | ≥ 1 year |
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