| 货号 | 589201-480Well |
| 描述 | Tumor Necrosis Factor-α (TNF-α) is a 17 kDa polypeptide produced primarily by activated monocytes and macrophages. This polypeptide mediates many immune and inflammatory responses, including activation and differentiation of monocytes and macrophages, expression of MHC class I and II, and expression of adhesion molecules on endothelial cells.1,2,3 TNF-α is considered to be the primary mediator in many inflammatory conditions including toxic shock and sepsis.4,5 Cayman’s TNF-α assay is an immunometric (i.e., sandwich) ELISA that permits TNF-α measurements within the range of 3.9-250 pg/ml, typically with a limit of detection of 3.9 pg/ml. Inter- and intra-assay CVs of less than 5% can be achieved at most concentrations. This assay allows sensitive, specific analysis of TNF-α in serum or plasma. |
| 别名 | Tumor Necrosis Factor-α (human) EIA Kit; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vassalli, P. The pathophysiology of tumor necrosis factors. Annual Reviews of Immunology 10, 411-452 (1992). 2.Pober, J.S.,Lapierre, L.A.,Stolpen, A.H., et al. Activation of cultured human endothelial cells by recombinant lymphotoxin: Comparison with tumor necrosis factor and interleukin 1 species. Journal of Immunology 138, 3319-3324 (1987). 3.Broudy, V.C.,Harlan, J.M. and Adamson, J.W. Disparate effects of tumor necrosis factor-α/cachectin and tumor necrosis factor-β/lymphotoxin on hematopoietic growth factor production and neutrophil adhesion molecule expression by cultured human endothelial cells. Journal of Immunology 138, 4298-4302 (1987). 4.Beutler, B.,Greenwald, D.,Hulmes, J.D., et al. Identity of tumor necrosis factor and the macrophage-secreted factor cachectin. Nature 316, 552-554 (1985). 5.Tracey, K.J.,Beutler, B.,Lowry, S.F., et al. Shock and tissue injury induced by recombinant human cachectin. Science 234, 470-474 (1986). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
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