| 货号 | 583301-480Well |
| 描述 | Interleukin-1 (IL-1) is a name for a family of proteins which include IL-α, IL-1β, ILra (interleukin receptor antagonist), and IL-18. IL-1α is synthesized as a 33 kDa (271 amino acid) pro-cytokine that is enzymatically cleaved by calpain into the active 159 amino acid, 17 kDa peptide.1,2,3 IL-1α is produced by many cells types including macrophages, monocytes, astrocytes, keratinocytes, adipocytes, T-cells, and eosinophils.4 Although IL-1α and IL-1β exhibit only 26% amino acid identity,1 they bind to the same cell-surface receptors, IL-1 RI and IL-1 RII, present on a variety of cell types involved in immune or inflammatory responses.5,6,7 Normal production of IL-1 is critical for mediating host responses to infection and injury.8,9 Disease states in which IL-1 actively participates include inflammatory diseases such as arthritis, inflammatory bowel disease, and shock, as well as atherosclerosis, allergy, and some types of cancer.8,9 Cayman’s IL-1α (human) ELISA Kit is an immunometric (i.e., sandwich) ELISA that permits IL-1α measurements within the range of 3.9-250 pg/ml, typically with a limit of detection of 3.9 pg/ml. |
| 别名 | IL-1α (human) EIA Kit; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.March, C.J.,Mosley, B.,Larsen, A., et al. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 315, 641-647 (1985). 2.Kobayashi, Y.,Yamamoto, K.,Saido, T., et al. Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1α. Proceedings of the National Academy of Sciences of the United States of America 87, 5548-5552 (1990). 3.Watanabe, N. and Kobayashi, Y. Selective release of a processed form of interleukin 1α. Cytokine 6(6), 597-601 (1994). 4.Dinarello, C.A. Interleukin-1 and its biologically related cytokines. Advances in Immunology 44, 153-205 (1989). 5.Sims, J.E.,March, C.J.,Cosman, D., et al. cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 241, 585-589 (1988). 6.Sims, J.E.,Acres, R.B.,Grubin, C.E., et al. Cloning the interleukin 1 receptor from human T cells. Proceedings of the National Academy of Sciences of the United States of America 86, 8946-8950 (1989). 7.McMahan, C.J.,Slack, J.L.,Mosley, B., et al. A novel IL-1 receptor, cloned from B cells by mammaliam expression, is expressed in many cell types. EMBO Journal 10(10), 2821-2832 (1991). 8.Dinarello, C.A. Interleukin-1 and the pathogenesis of the acute-phase response. New England Journal of Medicine 311, 1413-1418 (1984). 9.Rosenwasser, L.J. Biologic activities of IL-1 and its role in human disease. Journal of Allergy and Clinical Immunology 102, 344-350 (1998). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
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