AZD 3988 (50 MG)
货号：
4837/50 基本售价：
18817.7 元 规格：
50 mg
产品信息
概述| 货号 | 4837/50 |
| 别名 | trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 456.44 |
| 分子式 | C23H22F2N4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in 1eq. NaOH with gentle warming |
| 参考文献 | McCoullet al (2012) Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg.Med.Chem.Lett. 22 3873. PMID: 22608962. |
