| 货号 | 9000405-5mg |
| 描述 | Prostaglandin E1(PGE1) is produced by the metabolism of dihomo-γ-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC50 = 40 nM)1,2 and increases vasodilation. 13,14-dihydro-16,16-difluoro PGE1 is an analog of PGE1. 13,14-dihydro PGE1 is a biologically active metabolite of PGE1, inhibiting platelet aggregation with comparable potency to the parent compound.3,2 The addition of two electron-withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradation in vivo.4 |
| 别名 | 15-hydroxy Lubiprostone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kobzar, G.,Mardla, V.,Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proceedings of the Estonian Academy of Sciences.Chemistry 40, 179-180 (1991). 2.Westwick, J. The effect of pulmonary metabolites of prostaglandins E1, E2 and F2α on ADP-induced aggregation of human and rabbit platelets. British Journal of Pharmacology 58, 297P-298P (1976). 3.Peskar, B.A.,Cawello, W.,Rogatti, W., et al. On the metabolism of prostaglandin E1 administered intravenously to human volunteers. Journal of Physiology and Pharmacology 42, 327-331 (1991). 4.Hatano, Y.,Kohli, J.D.,Goldberg, L.I., et al. Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclin. Proceedings of the National Academy of Sciences of the United States of America 77(11), 6846-6850 (1980). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 392.5 |
| 分子式 | C20H34F2O5 |
| CAS号 | 475992-30-4 |
| 稳定性 | ≥ 1 year |
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