R-Palmitoyl-(1-methyl) Ethanolamide
货号：
90353-500mg 基本售价：
18480.0 元 规格：
500 mg
产品信息
概述| 货号 | 90353-500mg |
| 描述 | Palmitoyl ethanolamide (PEA) is an endogenous cannabinoid found in brain, liver, and other mammalian tissues.1 PEA has also been isolated from egg yolk, and found to have anti-anaphylactic and anti-inflammatory activity in vitro.2 R-Palmitoyl-(1-methyl) ethanolamide is a synthetic analog of PEA which incorporates an (R)-methyl group vicinal to the alcohol on the ethanolamine moiety. The analogous modification to arachidonoyl ethanolamide (AEA) protects the molecule from hydrolysis by fatty acid amide hydrolase. This leads to prolonged duration of action and enhanced potency in vivo.3 R-palmitoyl-(1-methyl) ethanolamide would be expected to show enhancement of the inhibitory action of PEA on mast cells and other cells known to express the CB2 receptor. However, there are no published studies on the use of this compound to date. |
| 别名 | R-1 PMA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bachur, N.R.,Masek, K.,Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. The Journal of Biological Chemisty 240, 1019-1024 (1965).
2.Ganley, O.H.,Graessle, O.E.,Robinson, H.J., et al. Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithin. Journal of Laboratory and Clinical Medicine 51, 709-714 (1958).
3.Abadji, V.,Lin, S.,Taha, G., et al. (R)-Methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability. Journal of Medicinal Chemistry 37, 1889-1893 (1994).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 313.5 |
| 分子式 | C19H39NO2 |
| CAS号 | 142128-47-0 |
| 稳定性 | ≥ 2 years |
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