| 货号 | 19448-5mg |
| 描述 | Phomopsins are a family of mycotoxins produced by the fungus D. toxica, which predominantly infects lupines. Ingestion of lupines infected with D. toxica causes lupinosis, a degenerative disorder that can result in acute liver damage, brain damage, and death.1 Phomopsin A is a cyclic hexapeptide mycotoxin that binds β-tubulin in a vinca domain, overlapping with the site targeted by vinblastine (Item No. 11762) and other tubulin inhibitors.2,3 It binds β-tubulin from higher organisms but not α-tubulin or fungal mycelial tubulin.4,5 Phomopsin A blocks microtubule growth, modulates the dynamics of microtubules, and interferes with mitosis.5 |
| 别名 | NSC 381839; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cowley, r.,Luckett, D.J.,Ash, G.J., et al. Identification of QTLs associated with resistance to Phomopsis pod blight (Diaporthe toxica) in Lupinus albus. Breed Sci. 64(1), 83-89 (2014). 2.Hamel, E. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacology & Therapeutics 55(1), 31-51 (1992). 3.Cormier, A.,Marchand, M.,Ravelli, R.B.G., et al. Structural insight into the inhibition of tubulin by vinca domain peptide ligands. EMBO reports 9(11), 1101-1106 (2008). 4.Li, Y.,Kobayashi, H.,Hashimoto, Y., et al. Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulins. Biochemical and Biophysical Research Communications 187(2), 722-729 (1992). 5.Mitra, A. and Sept, D. Localization of the antimitotic peptide and depsipeptide binding site on β-tubulin. Biochemistry 43(44), 13955-13962 (2004). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 789.2 |
| 分子式 | C36H45ClN6O12 |
| CAS号 | 64925-80-0 |
| 稳定性 | ≥ 2 years |
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