| 货号 | 4899/50 |
| 别名 | N-(6-Chloro-7-methoxy-9H-pyrido[3,4 |
| 供应商 | Tocris |
| 生物活性 | Novel, ATP-competitive IKK2-selective inhibitor (IC50 = 60 nM at 50 μM ATP). Exhibits no inhibition at IKK1 (EC50>100μM), IKKε(EC50>100μM) or a panel of 28 other kinases (EC50>50μM). Exhibits antitumor activity in lymphoma-bearing SCID mice. Demonstrates synergistic cytotoxic effects with vincristine (Cat. No. 1257). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 439.72 |
| 分子式 | C19H15ClN4O2 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 5 mM in water with gentle warming |
| 参考文献 | Al-Katibet al (2010) I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma. Mol.Cancer 9 1476. PMID: 20809973. Catleyet al (2006) Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol.Pharmacol. 70 697. PMID: 16687566. Nagashimaet al (2006) Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta. Blood 107 4266. PMID: 16439676. |