货号 | 13821-50mg |
描述 | Misoprostol is a prostaglandin E1 (Item No. 13010) analog with agonist activity mediated by EP2, EP3, and EP4receptors.1,2,3,4 It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 µg/kg),2 inhibit superoxide generation in human neutrophils (EC50 = 0.35 µM),3 and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM)4 in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; Item No. 10006317) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.1 |
供应商 | Cayman |
应用文献 | |
1.Walt, R.P. Misoprostol for the treatment of peptic ulcer and antiinflammatory-drug-induced gastroduodenal ulceration. New England Journal of Medicine 327, 1575-1580 (1992). 2.Bunce, K.T.,Clayton, N.M.,Coleman, R.A., et al. GR63799X - a novel prostanoid with selectivity for EP3 receptors. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 21, 379-382 (1990). 3.Talpain, E.,Armstrong, R.A.,Coleman, R.A., et al. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils. British Journal of Pharmacology 114, 1459-1465 (1995). 4.Smith, G.C.S.,Coleman, R.A. and McGrath, J.C. Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus. Journal of Pharmacology and Experimental Therapeutics 271, 390-396 (1994). | |
运输条件 | Wet ice in continental US; may vary elsewhere |
存放说明 | -20 |
纯度 | ≥97% |
计算分子量 | 368.5 |
分子式 | C21H36O5 |
CAS号 | 112137-89-0 |
稳定性 | ≥ 1 year |
本官网所有报价均为常温或者蓝冰运输价格,如有产品需要干冰运输,需另外加收干冰运输费。 |