CAY10576
货号：
10011249-50mg 基本售价：
17640.0 元 规格：
50 mg
产品信息
概述| 货号 | 10011249-50mg |
| 描述 | The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKKα and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells, and is thought to play a role in the immune response. CAY10576 is a benzimidazole analog that selectively inhibits IKK-ε with an IC50 value of 40 nM and is essentially inactive at IKK-α and IKK-β.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bamborough, P.,Christopher, J.A.,Cutler, G.J., et al. 5-(1H-benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase. Bioorganic & Medicinal Chemistry Letters 16, 6236-6240 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 469.5 |
| 分子式 | C22H19N3O5S2 |
| CAS号 | 862812-98-4 |
| 稳定性 | ≥ 2 years |
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