CAY10535
货号：
10010396-50mg 基本售价：
17640.0 元 规格：
50 mg
产品信息
概述| 货号 | 10010396-50mg |
| 描述 | TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2(TXA2). Although their distinct physiological functions have not been fully elucidated, TPβ is believed to be responsible for vascular endothelial growth factor-induced endothelial cell differentiation and migration whereas TPα appears to be the predominant isoform expressed in platelets. CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for TPβ (IC50 = 99 nM) relative to TPα (IC50 = 1,970 nM) in the inhibition of U46619-mediated Ca2+ mobilization. This compound exhibits relatively poor activity on platelets (IC50 = 985 nM) when inhibiting U-46619-induced platelet aggregation.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hanson, J.,Dogné, J.M.,Ghiotto, J., et al. Design, synthesis, and SAR study of a series of N-alkyl-N-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as selective antagonists of the TPα and TPβ isoforms of the human thromboxane A2 receptor. Journal of Medicinal Chemistry 50(16), 3928-3936 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 423.4 |
| 分子式 | C18H21N3O7S |
| CAS号 | 945716-28-9 |
| 稳定性 | ≥ 2 years |
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