| 货号 | 4673/50 |
| 别名 | [5-(2-Fluorophenyl)-2-methyl-4-thia |
| 供应商 | Tocris |
| 生物活性 | Potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM). Exhibits 100-fold selectivity for OX1 over OX2 receptors. Has no effect at serotonergic, dopaminergic, adrenergic or purinergic receptors. Inhibits orexin 1-induced Ca2+ mobilization in CHO-DG44 cells stably transfected with the OX1receptor. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 448.51 |
| 分子式 | C24H21FN4O2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Elliset al (2006) Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. Biol.Chem. 281 38812. PMID: 17015451. Langmeadet al (2004) Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br.J.Pharmacol. 141 340. PMID: 14691055. |