| 货号 | 10007737-100ug |
| 描述 | Lipoxin A4-d5(LXA4-d5) contains five deuterium atoms at the 19, 19’, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of LXA4 by GC- or LC-mass spectrometry (MS). LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.1LXA4 is equipotent to leukotriene B4(LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM.2LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.2,3,4 |
| 别名 | 5(S),6(R),15(S)-TriHETE-d5;5(S),6(R)-LXA4-d5; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Serhan, C.N.,Nicolaou, K.C.,Webber, S.E., et al. Lipoxin A. Stereochemistry and biosynthesis. The Journal of Biological Chemisty 261, 16340-16345 (1986). 2.Serhan, C.N.,Hamberg, M., and Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proceedings of the National Academy of Sciences of the United States of America 81, 5335-5339 (1984). 3.Ramstedt, U.,Serhan, C.N.,Nicolaou, K.C., et al. Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: Studies on stereospecificity of inhibition and mode of action. Journal of Immunology 138, 266-270 (1987). 4.Maddox, J.F., and Serhan, C.N. Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: Selective inactivation by dehydrogenation and reduction. Journal of Experimental Medicine 183, 137-146 (1996). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥99% deuterated forms (d1-d5) |
| 计算分子量 | 357.5 |
| 分子式 | C20H27D5O5 |
| 稳定性 | ≥ 1 year |
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