15-keto Fluprostenol isopropyl ester
货号：
16786-25mg 基本售价：
17402.0 元 规格：
25 mg
产品信息
概述| 货号 | 16786-25mg |
| 描述 | Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1,2 Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals. 15-keto Travoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response.3 The efficacy of 15-keto travoprost as an ocular hypotensive has not been established. |
| 别名 | 15-keto Travoprost; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sorbera, L.A. and Castañer, J. Travoprost. Drugs of the Future 25, 41-45 (2000).
2.Hellberg, M.R.,Sallee, V.L.,McLaughlin, M.A., et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. Journal of Ocular Pharmacology and Therapeutics 17(5), 421-432 (2001).
3.Taniguchi, T.,Haque, M.S.R.,Sugiyama, K., et al. Ocular hypotensive mechanism of topical isopropyl unoprostone, a novel prostaglandin metabolite-related drug, in rabbits. Journal of Ocular Pharmacology 12, 489-498 (1996).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 498.5 |
| 分子式 | C26H33F3O6 |
| CAS号 | 404830-45-1 |
| 稳定性 | ≥ 2 years |
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