| 货号 | 4144/50 |
| 别名 | 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl) |
| 供应商 | Tocris |
| 生物活性 | ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 425.48 |
| 分子式 | C21H27N7O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Heerdinget al (2008) Identification of 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{(3S)-3-piperidinylmethoxyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J.Med.Chem. 51 5663. PMID: 18800763. Rhodeset al (2008) Characterization of an Akt inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res. 68 2366. PMID: 18381444. |