LY293111
货号：
10009768-10mg 基本售价：
16856.0 元 规格：
10 mg
产品信息
概述| 货号 | 10009768-10mg |
| 描述 | Leukotriene B4(LTB4) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. LY293111 is a potent antagonist of the leukotriene B4(LTB4) receptor, BLT1, that inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 17.6 nM and inhibits the LTB4-induced chemotaxis of human neutrophils with an IC50 value of 6.3 nM.1 LY293111 inhibits growth of MiaPaCa-2 and AsPC-1 human pancreatic cancer cells in vitro (250-1,000 nM) and subcutaneous xenografts in athymic mice (250 mg/kg/day), inducing apoptosis and S-phase arrest.2 |
| 别名 | Etalocib;VML 295; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jackson, W.T.,Froelich, L.L.,Boyd, R.J., et al. Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: In vitro studies. Journal of Pharmacology and Experimental Therapeutics 288(1), 286-294 (1999).
2.Tong, W.G.,Ding, X.Z.,Hennig, R., et al. Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Clinical Cancer Research 8, 3232-3242 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 543.6 |
| 分子式 | C33H33FO6 |
| CAS号 | 161172-51-6 |
| 稳定性 | ≥ 2 years |
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