| 货号 | 10009993-500ug |
| 描述 | (±)9(10)-DiHOME-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of (±)9(10)-DiHOME by GC- or LC-mass spectrometry (MS). Leukotoxin is the 9(10) epoxide of linoleic acid (Item No. 90150), generated by neutrophils during the oxidative burst.1,2,3 This unstable compound is rapidly degraded by epoxide hydrolases to form the diol, (±)9(10)-DiHOME (Item No. 53400).4 Mitochondrial dysfunction, vasodilation, and apoptosis are features of leukotoxin toxicity. In renal proximal tubular cells, the diol hydrolysis products of leukotoxin, such as (±)9(10)-DiHOME, have been directly implicated as the cytotoxic agent responsible for cell death.5 |
| 别名 | Leukotoxin diol-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hayakawa, M.,Sugiyama, S.,Takamura, T., et al. Neutrophils biosynthesize leukotoxin, 9,10-epoxy-12-octadecenoate. Biochemical and Biophysical Research Communications 137, 424-430 (1986). 2.Ishizaki, T.,Takahashi, H.,Ozawa, T., et al. Leukotoxin, 9,10-epoxy-12-octadecenoate causes pulmonary vasodilation in rats. Journal of the American Physiological Society 1040, L123-L128 (1995). 3.Ozawa, T.,Hayakawa, M.,Takamura, T., et al. Biosynthesis of leukotoxin, 9,10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxia. Biochemical and Biophysical Research Communications 134, 1071-1078 (1986). 4.Greene, J.F.,Williamson, K.C.,Newman, J.W., et al. Metabolism of monoepoxides of methyl linoleate: Bioactivation and detoxification. Archives of Biochemistry and Biophysics 376, 420-432 (2000). 5.Moran, J.H.,Weise, R.,Schnellmann, R.G., et al. Cytotoxicity of linoleic acid diols to renal proximal tubular cells. Toxicology and Applied Pharmacology 146, 53-59 (1997). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 318.5 |
| 分子式 | C18H30D4O4 |
| 稳定性 | ≥ 1 year |
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