| 货号 | 10009027-5mg |
| 描述 | 6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel (Item No. 10461), produced by the action of the cytochrome P450 isoform CYP2C8.1,2 The generation of 6α-hydroxy paclitaxel by CYP2C8 can be impacted by other drugs (e.g., fluvastatin, Item No. 10010334) or dietary components that interefere with CYP2C8 activity, as well as by CYP2C8 genetic polymorphisms.3,4,5 |
| 别名 | 6α-hydroxy Taxol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kumar, G.N.,Oatis, J.E., Jr.,Thornburg, K.R., et al. 6 alpha-Hydroxytaxol: Isolation and identification of the major metabolite of taxol in human liver microsomes. Drug Metabolism and Disposition 22, 177-179 (1994). 2.Walle, T.,Kumar, G.N.,McMillian, J.M., et al. Taxol metabolism in rat hepatocytes. Biochemical Pharmacology 46(9), 1661-1664 (1993). 3.Fischer, V.,Johanson, L.,Heitz, F., et al. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: Effect on human cytochrome P-450 and implications for metabolic drug interactions. Drug Metabolism and Disposition 27(3), 410-416 (1999). 4.Quintieri, L.,Palatini, P.,Moro, S., et al. Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin. Drug Metab.Pharmacokinet. 26(6), 559-568 (2011). 5.Saito, Y.,Katori, N.,Soyama, A., et al. CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population. Pharmacogenetics and Genomics 17(7), 461-471 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 869.9 |
| 分子式 | C47H51NO15 |
| CAS号 | 153212-75-0 |
| 稳定性 | ≥ 2 years |
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