| 货号 | 16465-5mg |
| 描述 | U-51605 is a stable analog of the endoperoxide prostaglandin H2(PGH2). It is an inhibitor of both prostacyclin (PGI) and thromboxane (TX) synthases with more selectivity towards PGI synthase. U-51605 is also a partial agonist at TP receptors.1 In human foreskin fibroblasts, U-51605 inhibits PGI synthase at a concentration of 2.8 µM, whereas, human platelet TX synthase is inhibited at a concentration of 5.6 µM.2,3 At concentrations up to 1 µM, U-51605 reduced the release of prostacyclin in SHR aorta elicited by the calcium ionophore A-23187 with no effect on TXA2 production and yet significantly increased PGE2 and PGF2αrelease.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Needleman, P.,Bryan, B.,Wyche, A., et al. Thromboxane synthetase inhibitors as pharmacological tools: Differential biochemical and biological effects on platelet suspensions. Prostaglandins 14, 897-907 (1977). 2.Gorman, R.R.,Hamilton, R.D. and Hopkins, N.K. Stimulation of human foreskin fibroblast adenosine 3:5-cyclic monophosphate levels by prostacyclin (prostaglandin I2). The Journal of Biological Chemisty 254, 1671-1676 (1979). 3.Gorman, R.R.,Bundy, G.L.,Peterson, D.C., et al. Inhibition of human platelet thromboxane synthetase by 9,11-azoprosta-5,13-dienoic acid. Proceedings of the National Academy of Sciences of the United States of America 74, 4007-4011 (1977). 4.Gluais, P.,Paysant, J.,Badier-Commander, C., et al. In SHR aorta, calcium ionophore A-23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors. American Journal of Physiology.Heart and Circulatory Physiology 291, H2255-H2264 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 332.5 |
| 分子式 | C20H32N2O2 |
| CAS号 | 64192-56-9 |
| 稳定性 | ≥ 1 year |
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