Butaprost (free acid)
货号：
13741-10mg 基本售价：
16660.0 元 规格：
10 mg
产品信息
概述| 货号 | 13741-10mg |
| 描述 | Butaprost is an EP2 selective agonist which has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells.1,2 Prostaglandin free acids generally bind to their cognate receptors with 10 to 100 times the affinity of the corresponding ester derivative. Consistent with this trend, butaprost binds to membranes from EP2 receptor-transfected CHO cells with a Ki value of 2,400 nM, whereas butaprost (free acid) and CAY10399 (the 2-series congener of butaprost free acid) exhibit significantly lower Ki values of 73 and 92 nM, respectively.3 Butaprost (free acid) is therefore another useful tool for characterizing EP receptor-mediated signalling events. |
| 别名 | (±)-15-deoxy-16S-hydroxy-17-cyclobutyl PGE1;15-deoxy-16S-hydroxy-17-cyclobutyl PGE1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kiriyama, M.,Ushikubi, F.,Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. British Journal of Pharmacology 122, 217-224 (1997).
2.Lawrence, R.A. and Jones, R.L. Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein. British Journal of Pharmacology 105, 817-824 (1992).
3.Tani, K.,Naganawa, A.,Ishida, A., et al. Design and synthesis of a highly selective EP2-receptor agonist. Bioorganic & Medicinal Chemistry Letters 11, 2025-2028 (2001).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 394.6 |
| 分子式 | C23H38O5 |
| CAS号 | 433219-55-7 |
| 稳定性 | ≥ 2 years |
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