Rp-8-bromo-Cyclic AMPS (sodium salt)
货号：
21584-5mg 基本售价：
16576.0 元 规格：
5 mg
产品信息
概述| 货号 | 21584-5mg |
| 描述 | Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.1,2 It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.2 |
| 别名 | 8-Bromoadenosine 3,5-cyclic monophosphorothioate, Rp-isomer;Rp-8-Br-cAMPS;Rp-8-bromo-cAMPS; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dostmann, W.R.,Taylor, S.S.,Genieser, H.G., et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3,5-cyclic phosphorothioates. J. Biol. Chem. 265(18), 10484-10491 (1990).
2.Gjertsen, B.T.,Mellgran, G.,Otten, A., et al. Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1β action. J. Biol. Chem. 270(35), 20599-20607 (1995).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 446.1 |
| 分子式 | C10H10BrN5O5PS • Na |
| CAS号 | 925456-59-3 |
| 稳定性 | ≥ 2 years |
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