| 货号 | 9002078-5mg |
| 描述 | Oleic acid (Item No. 90260) is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1 Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 µg/ml.1 fMLF-induced neutrophil aggregation and degranulation is inhibited by 55% and 68%, respectively, using 5 µM oleic acid. This inhibition is comparable to that observed using arachidonic acid (Item No. 90010) under the same conditions.2 Oleic acid, whether applied extracellularly (EC50 = ~60 µM) to human platelets or released from membrane phospholipids, causes an increase in intracellular calcium levels.3 Oleic acid alkyne is a form of oleic acid with an ω-terminal alkyne. The terminal alkyne group can be used in click chemistry linking reactions, to tag oleic acid with fluorescent or biotinylated labels for analysis of its metabolism and biological activity.4,5,6,7 |
| 别名 | Click Tag™ Oleic Acid Alkyne; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wahle, K.W.J. and Peacock, L.I.L. Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet function. Biochimica et Biophysica Acta 1301, 141-149 (1996). 2.Naccache, P.H.,Moiski, T.F.P.,Volpi, M., et al. Modulation of rabbit neutrophil aggregation and degranulation by free fatty acids. Journal of Leukocyte Biology 36, 333-340 (1984). 3.Siafaka-Kapadai, A.,Hanahan, D.J. and Javors, M.A. Oleic acid-induced Ca2+ mobilization in human platelets: Is oleic acid an intracellular messenger? Journal of Lipid Mediators and Cell Signalling 15, 215-232 (1997). 4.Kolb, H.C. and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discovery Today 8(24), 1128-1137 (2003). 5.Lutz, J.F. and Zarafshani, Z. Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry. Advanced Drug Delivery Reviews 60, 958-970 (2008). 6.Vila, A.,Tallman, K.A.,Jacobs, A.T., et al. Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. Chemical Research in Toxicology 21(2), 432-444 (2008). 7.Jiang, H.,Khan, S.,Wang, Y., et al. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110-113 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 278.4 |
| 分子式 | C18H30O2 |
| CAS号 | 151333-45-8 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |