Xestospongin C
货号：
64950-250ug 基本售价：
16184.0 元 规格：
250 ug
产品信息
概述| 货号 | 64950-250ug |
| 描述 | Xestospongin C is a marine natural product which was first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Xestospongin C antagonizes the calcium-releasing action of inositol-1,4,5-trisphosphate (IP3) at the receptor level. Inositol phosphates are important signal transduction messengers acting viaIP3 receptors to promote the mobilization of Ca2+ from intracellular stores. Xestospongin C blocks the increase in intracellular calcium in vascular smooth muscle cells completely at a concentration of 25 µM.2 Xestospongin C also inhibits the sarcoplasmic reticulum Ca2+ ATPase pump at concentrations of 700 nM.3 |
| 别名 | XeC;Araguspongine E; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nakagawa, M. and Endo, M. Structures of xestospongin A, B, C and D, novel vasodilative compounds from marine sponge, Xestospongia exigua. Tetrahedron Letters 25(30), 3227-3230 (1984).
2.Gafni, J.,Munsch, J.A.,Lam, T.H., et al. Xestospongins: Potent membrane permeable blockers of the inositol 1,4,5-triphosphate receptor. Neuron 19, 723-733 (1997).
3.Castonguay, A. and Robitaille, R. Xestospongin C is a potent inhibitor of SERCA at a vertabrate synapse. Cell Calcium 32(1), 39-47 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 446.7 |
| 分子式 | C28H50N2O2 |
| CAS号 | 88903-69-9 |
| 稳定性 | ≥ 1 year |
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