| 货号 | 5330/50 |
| 别名 | 222,Trifluoro-N-[[(2S)-1-(N-methyl- |
| 供应商 | Tocris |
| 生物活性 | IAP antagonist; binds to the BIR3 domain of cIAP1, cIAP2 and XIAP with nanomolar affinity. Reduces cIAP1, cIAP2 and XIAP protein levels in human breast cancer MDA-MB-231 cells. Induces apoptosis in combination with TNF, and potentiates TRAIL-mediated apoptosis in human colorectal carcinoma HCT 116 cells. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 1120.06 |
| 分子式 | C52H68F6N8 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Beuget al (2014) Smac mimetics and innate immune stimuli synergize to promote tumor death. Nat.Biotechnol. 32 182. PMID: 24463573. Galbánet al (2009) Cytoprotective effects of IAPs revealed by a small molecule antagonist. Biochem.J. 417 765. PMID: 18851715. Bertrandet al (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 30 689. PMID: 18570872. |