W123
货号：
10010992-25mg 基本售价：
15680.0 元 规格：
25 mg
产品信息
概述| 货号 | 10010992-25mg |
| 描述 | Sphingosine-1-phosphate (S1P) modulates skin, vascular endothelial, and immune cells via five distinct G protein-coupled receptors. The S1P type 1 receptor, S1P1, also known as EDG-1, mediates endothelial, lymphoid, and neuronal cell responses to S1P, as well as the synthetic agonist FTY720. W123 is an analog of FTY720 that is a competitive antagonist of S1P1, as measured by GTPγS activation, mitogen-activated protein kinase recruitment, cell migration, and ligand-induced receptor internalization.1 It has a Ki value of 0.69 μM when assessed by SEW2871-induced activation of S1P1.1 Its specificity for other S1P receptor subtypes remains to be determined. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wei, S.H.,Rosen, H.,Matheu, M.P., et al. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nature Immunology 6(12), 1228-1235 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 306.4 |
| 分子式 | C17H26N2O3 |
| CAS号 | 1345982-24-2 |
| 稳定性 | ≥ 2 years |
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