| 货号 | 5455/50 |
| 别名 | N-[[4-(Dimethylamino)phenyl]methyl] |
| 供应商 | Tocris |
| 生物活性 | High affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 493.08 |
| 分子式 | C30H36N2O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Choet al (2014) Autocrine effects of tumor-derived complement. Cell Rep. 6 1085. PMID: 24613353. Monket al (2007) Function, structure and therapeutic potential of complement C5a receptors. Br.J.Pharmacol. 152 429. PMID: 17603557. Sumichikaet al (2002) Identification of a potent and orally active non-peptide C5a receptor antagonist. J.Biol.Chem. 277 49403. PMID: 12384495. |