| 货号 | 5832/50 |
| 别名 | 7-Methyl-2-(4-morpholinyl)-9-[1-(ph |
| 供应商 | Tocris |
| 生物活性 | Potent and selective PI 3-kinase β inhibitor (IC50 values are 0.007, 0.1, 3.5 and 5 μM for the β,δ,γandα isoforms, respectively). Shows >1,000-fold selectively for PI 3-kinase β over a range of other kinases. Inhibits thrombus formation in animal models. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 364.44 |
| 分子式 | C21H24N4O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Condliffeet al (2005) Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106 1432. PMID: 15878979. Jacksonet al (2005) PI 3-kinase p110β: a new target for antithrombotic therapy. Nat.Med. 11 507. PMID: 15834429. |